Prostate cancer is
a malignant tumor. It initiates in the male genital gland which is situated
between the base of the bladder and the penis. Prostate Specific Antigen (PSA)
is a protein that is produced by prostate cells and secreted into the blood
stream. Its level might be increased in many benign and malignant conditions
such as prostate cancer, benign hyperplasia as well as infections or even
prostate examination through digital rectal exam (DRE); however, its serum
level has been suggested as a tumor marker for both prostate cancer screening
and follow up respectively. There are various types of cells which found in the
prostate gland, but most of the prostate cancer grows through the gland cells.
These cells build the prostate fluid which is added to the semen. There are
several options are available in the immune-oncology or immunotherapy to treat
this type of cancers. These immune-oncology deliver the immunity to the patient
body and also kill the cancerous cells.
In 2015, American
Cancer Society estimates 220,800 new cases and 27,540 deaths due to prostate
cancer in the United States. In 2012, it was the third most indentified cancer
after breast cancer or colorectal cancer with at 417,000 cases in the Europe.
The age-standardized rate of incidence of prostate cancer was 83.8 per 100,000
and mortality rate of 9.7%, respectively and it accounts 13% of all the cancers
and it occurs between age of 65 or older. The most common risk factors of
prostate cancer are smoking, inflammation of the prostate, vasectomy, workplace
exposures, obesity, gene changes, family history, diet, race/ethnicity, and
age. The prostate cancer occurs due to the DNA alteration in the prostate
cells. The prostate cancer can be diagnosed with the help of prostate-specific
antigen (PSA) test of blood and digital rectal exam (DRE).
The immunotherapy
plays a important role in the treatment of prostate cancer. Sipuleucel-T
(Provenge) is a vaccine which is most commonly used for the treatment of this
cancer. This is a cancer vaccine that boosts the immunity of the body to treat
this cancer in refractory and relapsed settings and particularly in castration
resistant cases. There are several antibody drug conjugates, monoclonal
antibody, kinase inhibitor drugs, vaccines, immunomodulators, mTOR drugs, and
interleukins. All these immunotherapeutic are having specific potency to fight
against the cancerous cells. These immunotherapeutic binds to different target
and cure the prostate gland and destroy all the cancerous cells. Immunotherapy
plays a effective role in the treatment of prostate cancer as compare to other
treatments.
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