If you’re trying to understand the functions
of immune oncology cells that constantly come up as you study the different types of
treatments of immunotherapy, then this Q&A blogpost will serve you well in
understanding the basics when it comes to that specifically knowing what are
white blood cells, their types & the function of the most basic form of
defense of them.
So what is the innate immune system again?
Its part of the layered immune system, and
it’s the first line of defense against all forms of pathogens & foreign
bodies, and its defenses are mainly non-specific as opposed to the adaptive
immune system which is the more advanced component of the immune system.
 |
| www.gapsos.com |
And what exactly these cellular barriers?
These are the types of cells within the
innate immune system that are responsible for the defensive immune response
against the pathogens to be able to eradicate them completely and end the form
of threat coming up.
And what are these cells?
Mainly it’s the leukocytes or white blood
cells which are considered to be the second hand of the innate immune system
and it has many types.
What are the types of the white blood cells?
Phagocytes (dendritic cells, neutrophils
& macrophages),eosinophils,basophils, mast cells & NK cells.
And what is the main ways these cells attack
the pathogens?
They’re mainly generic and are activated
through what is called pathogen recognition receptors present of their cell’s
surface and the ways through which they attack are 2 ways:
1-Attacking larger pathogens through contact.
2-Through the engulfment & killing of
them.
And what are phagocytes?
These are immune cells belonging to the
leukocytes that protect the body through ingesting harmful particles or
pathogens.
And what is phagocytosis?
This is the function of phagocytes which is
engulfment, and it’s considered to be the most basic form of defense in
invertebrates & vertebrates alike.
And how does phagocytosis happens?
Mainly these phagocytes go about patrolling
the body looking for pathogens to present themselves though they can also be
called to certain locations through cytokines.
And when a pathogen is engulfed by a
phagocyte it turns into a phagosome through becoming trapped in an
intracellular vesicle and then turns into a phagolysosome through the fusion
with another vesicle called lysosome.
The pathogen is eliminated through the
digestive activity of enzymes or through the following of a respiratory
bursting that leads to the release of free radicals into the phagolysosome.
No comments:
Post a Comment