Uterine
cancer is one the leading causes of death related to cancer like disease across
the world. The majority of uterine cancer is adenocarcinomas which include
serous, mucinous, clear cell, and mixed cell. The epithelial non
adenocarcinomas include squamous cell carcinoma, small cell carcinoma,
transitional cell carcinoma, and undifferentiated carcinoma. Immunotherapy
treatments have various immunotherapeutic cancer agents which are used in all
types of this cancer.
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Several
risk factors are observed that involve age (postmenopausal after the age of 55
years, incidence rate is higher than 95 per 100,000 people in the age of 65
Years), endogenous estrogen exposure ( it causes early menarche, nulliparity,
infertility, late menopause, and estrogen producing tumor), exogenous estrogen
(Hormonal ReplacementTherapy and drugs such as
Tamoxifen), past medical history (diabetes mellitus, and hypertension),
history of endometrial atypical hyperplasia, family history (less than 1% of
uterine cancer is due to familial factors), history of breast cancer, and
genetic factors (mutations in the MLH1 or MSH2 Gene cause of defect in
hereditary nonpolyposis colorectal cancer
have 20% risk to developing endometrial cancer before the age of 50
years, and 60% risk after the age of 60 years)
Various
symptoms were observed in the advanced stage of this cancer that involves
vaginal bleeding in unexpected postmenopausal women (menorrhagia or
metrorrhagia ).Profuse watery discharge is another symptoms.Attention should be
paid to the duration and severity of the symptoms.
The
significant role play by immunotherapeutic cancer agent in Immunotherapy
for the treatment of uterine cancer that
involve monoclonal antibody drug, vaccine based immunotherapy, adoptive T cell
therapy. Kinase inhibitors, cytokines, and checkpoint inhibitors. These
immunotherapeutic cancer agents have common actions that are increasing the potential
of patient’s immune system to fight with specific cancer’s cell. In the present
time, no single immunotherapy based drug has received approval by the Food and
Drug Administration (FDA) for the treatment of this cancer, but much more are
under evaluation via passes through several pre clinical and clinical phases
(phase 1, phase 2, and phase 3) for FDA approval.
Bevacizumab
is a monoclonal antibody drug is running
in clinical trials (phase 2) under evaluation of safety and efficacy, and for
FDA approval. This drug inhibits the growth of specific cancer’s cell via
blocking the way of blood flow to the site of cancer.
Global
Allied pharmaceuticals (GAP) have number of immunotherapeutic cancer agents for
the treatment of cancer like disease such as uterine. GAP has a responsible
team of expert for immunotherapy and antibody drug conjugates.
For
more information kindly visit us at www.gapsos.com
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