If you’re a cancer patient and you’re
researching how passive immunotherapy
can help you combat the cancerous tumor and you have many questions about its
effectiveness and itslimitations, then this article will give you a brief idea
about, its most widely used application and the major limitations of it.
So what is passive immunotherapy?
It is mainly the modification of the immune
system responses to be able to produce a certain type of result, in this case
the attack of the cancerous tumor, but there are 2 types of it: active and
passive.
The passive type goes about its effectwithout
needing the immune system to be actively used for it to operate as opposed to
the active type that totally requires that immune system to be active and fully
operational for the effect to occur.
Can you explain further what you mean about
the passive type?
Sure, as an example, the most widely used
application of it is called monoclonal antibody immunotherapy, and this type is
made from antibodies that are designed outside the patient’s body and then
re-introduced into it once again, and thus it doesn’t need the immune system to
make them, as they’re already made, thus their dependency is not on the immune
system, it’s on these types of antibodies.
They’re widely used, but are they effective?
Well despite being widely used, they are not
as successful as expected.
How so?
Well to understand that you need to
understand its limitations in the first place.
Okay, so what are the major limitations for
this type of therapy?
Among the expectations blown is that nothing
is really as it seems, sometimes the products weren’t as specific as noted or
as pure, things that didn’t appear to be toxic, became toxic especially at
higher doses, but to be more specific.
For example, most of the oncologists
prescribe this treatment not as a first line of therapy, but go for it after
treatments like chemotherapy or radiation therapy, and after these destructive
therapies, many things could happen that could decrease the effectiveness
completely, because these therapies could lead to the change of the antigens
and if you’re targeting a specific antigen protein that’s not the same anymore,
it’s ineffective.
Also usually the immune system is too worn
out from all these destructive approaches, and thus this could lead to a 20-30%
effectiveness only.
Finally the toxicity especially in certain
high doses can be dangerous.
And thus this wraps up our exposure to the
world of passive immunotherapy for cancer treatments and its major limitations.
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