Monday 23 March 2015

Save your life with early detection of Prostate cancer.



Prostate cancer is a malignant tumor. It initiates in the male genital gland which is situated between the base of the bladder and the penis. Prostate Specific Antigen (PSA) is a protein that is produced by prostate cells and secreted into the blood stream. Its level might be increased in many benign and malignant conditions such as prostate cancer, benign hyperplasia as well as infections or even prostate examination through digital rectal exam (DRE); however, its serum level has been suggested as a tumor marker for both prostate cancer screening and follow up respectively. There are various types of cells which found in the prostate gland, but most of the prostate cancer grows through the gland cells. These cells build the prostate fluid which is added to the semen. There are several options are available in the immune-oncology or immunotherapy to treat this type of cancers. These immune-oncology deliver the immunity to the patient body and also kill the cancerous cells. 
 
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In 2015, American Cancer Society estimates 220,800 new cases and 27,540 deaths due to prostate cancer in the United States. In 2012, it was the third most indentified cancer after breast cancer or colorectal cancer with at 417,000 cases in the Europe. The age-standardized rate of incidence of prostate cancer was 83.8 per 100,000 and mortality rate of 9.7%, respectively and it accounts 13% of all the cancers and it occurs between age of 65 or older. The most common risk factors of prostate cancer are smoking, inflammation of the prostate, vasectomy, workplace exposures, obesity, gene changes, family history, diet, race/ethnicity, and age. The prostate cancer occurs due to the DNA alteration in the prostate cells. The prostate cancer can be diagnosed with the help of prostate-specific antigen (PSA) test of blood and digital rectal exam (DRE). 

The immunotherapy plays a important role in the treatment of prostate cancer. Sipuleucel-T (Provenge) is a vaccine which is most commonly used for the treatment of this cancer. This is a cancer vaccine that boosts the immunity of the body to treat this cancer in refractory and relapsed settings and particularly in castration resistant cases. There are several antibody drug conjugates, monoclonal antibody, kinase inhibitor drugs, vaccines, immunomodulators, mTOR drugs, and interleukins. All these immunotherapeutic are having specific potency to fight against the cancerous cells. These immunotherapeutic binds to different target and cure the prostate gland and destroy all the cancerous cells. Immunotherapy plays a effective role in the treatment of prostate cancer as compare to other treatments.

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