Awareness can save your life. It might be dangerous.

The Meningioma is a slow growing tumor that usually appears on the surface of the brain and shows significant symptoms, when it grows and presses on the brain or spinal cord. Meningioma is a type of tumor that takes part in the meninges, which are the slight membranes that envelop and shield the brain and spinal cord. About 80% of meningioma is benign type. It is thought that the role of Immunotherapy can boosts the body’s natural defenses to fight against the tumorcells; it functions by using the materials evoked from the body or by using in-vitro developed drugs and regulate the body immune system.

Based on its initiation in the CNS Meningioma is divided into different types they are Convexity meningioma, Sphenoid meningioma, Olfactory groove meningioma, Posterior fossa meningioma, Suprasellar meningioma, Spinal meningioma, Falx &parasagittal meningioma and Intraorbital meningioma.

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As per the data available within the United States itself meningioma occupies 35% among primary tumors and it takes place in about seven of every one lakh natives. Rarely seen in children. Survival rates for meningioma depend on some factors, together with the age of the patient and whether the tumor is cancerous.

Numerous risk factors are associated with this type of cancer is Age: People among the age groups of 30 & 70 are mostly prone to diagnosis with meningioma, Genetic disorders: People with NF2 are more likely to develop meningioma and finally it depends on Race/Ethnicity. Most common symptoms associated seen are convulsions, Motor seizures, and sudden involuntary movements of a person’s muscles, headache, weakness, confusion and numbness.

Primary step in diagnosis is to undergo the patient with physical examinations such as Neurological, vision, and hearing tests. Once after the physical examination, Imaging tests are of higher use when the results are compared with the patient’s medical history, neurological tests, and physical examination. Such imaging techniques include cerebral angiogram, Electroencephalography, Lumbar puncture, Stereotactic neurosurgery/Biopsy,MRI, X – rays and PET scan.

Recent advancements are on the way to present better treatment process for the patients, these include Anti-angiogenesis therapy generally inhibits the angiogenesis process via this mechanism it targets the tumor cells restricting their growth by making them on starving. It is consider as a kind of targeted therapy. Another advanced technique is gene therapy, which generally scans the faulty genes that are responsible for tumor growth. Researchers are trying to launch sophisticated therapies in the future that can serve the patients by curing the disease.

Global Allied Pharmaceuticals (GAP) has a professional team for Cancer related services. Our company is functioning to provide service at your door steps. 

Be in touch with Global Allied Pharmaceuticals to explore more on Cancer related assistance. We are privileged to serve you. Kindly visit http://www.gapsos.com/ for further queries.

A Predefined Study of Gastrointestinal stromal tumor.

A strange type of cancer named among the group of cancers. It may arise from either nerve or muscle tumors and recent studies suggest that they are found in the walls of the GI tract called Intestinal Cells of Cajal (ICC). Immunotherapy is considered as an essential tool to enhance the body's natural defenses making fit to fight against the GIST. It uses resources made either by the body or in a laboratory to reinforce, aim, or repair immune system role. Examples of immunotherapy take account of cancer vaccines, interferons and monoclonal antibodies.

 

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The projected data of 2014 concluded that about 4,000 -5,000 adults in the United States were get diagnosed to GIST. Chance of occurring GIST inside the body parts are stomach about 60% chance and small intestine is about 30% chance. Other forms of GIST start from esophagus, colon and rectum.Symptoms that are associated with GIST includes pain or discomfort in the abdomen, a mass in the abdomen that you can feel with your hand, Nausea and vomiting, Vomiting blood or having blood in the stool and Fatigue due to anemia.

Physical examination is an initial step in getting diagnosis includes the Blood test analysis. If the patient is get accused by disease the physician get suggests Imaging tests include X-ray, Bone scan, Computed tomography scan, Positron emission tomography (PET) scan and Magnetic resonance imaging (MRI). Surgical tests includes Biopsy, Bone marrow aspiration & biopsy and Post-biopsy laboratory tests that can clear Doctor’s dilemma that whether he needs to go for Chemotherapy or Radiation therapy. But the use of such therapies shows adverse effects on patients by enrolling with various side effects. 

At present researchers are trying to launch better Biological therapy that includes the use of Immune-Oncology, Immune combination therapy, Antibody drug conjugates and Monoclonal antibodies. Through this inventory patient can able to offer an affordable treatment. Among them most successful and available biological treatment method is by targeted therapy, generally blocks restrict the growth area of tumor cells via limiting the damage to healthy cells.

Approved targeted therapies that are avail in the market are Sunitinib, Imatinib and Regorafenib are broadly used for treating gastrointestinal stromal tumor.

Global Allied Pharmaceuticals (GAP) has a professional team for Cancer related services. Our company is functioning to provide service at your door steps. 

Be in touch with Global Allied Pharmaceuticals to explore more on Cancer related assistance. We are privileged to serve you. Kindly visit http://www.gapsos.com/ for further queries.

Introduction and application of Immunotherapeutic treatments.

Immunotherapy arose as an advanced and effective treatment to fight against cancer. With the help of this blog we are going to give you an introduction of immunotherapy, its applications and why it is the most used therapy these days. Immunotherapy is the treatment of any type of disease, through the enhancement, suppression, or induction of a response from the immune system. And to simplify it even further, it is used to either amplify or suppress an immunity effect. Simple, isn’t it! 

There are two main types of this immune based therapy such as Activation immune based therapy and Suppression Immune based therapies. Immunomodulators are mainly the active agents of this type of treatment which act either by activation of the immune system or by suppression of the immune system. And they are made of various preparations, that could be natural, synthetic or even recombinant, Cytokines are often the case, but let us take a look at several examples of them which include Cytokines such as Interferons, G-CSF, Chemokines such as CCL3, CCL26, Interleukins such as IL 2 to IL 12 and others like cytosine phosphate guano sine, glucans.

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These types of active agents are attractive for usage as a regimen because they often have side effects that are not as strong or unfavorable as drugs and also create less resistance when it comes to microbial diseases.

These immunomodulators are used for is called cell based immunotherapy, which has proven to be effective for some kind of cancer. Immune effector cells are like natural killer cells, dendritic cells, macrophages, cytotoxic T lymphocytes and so on.

Mainly the way to work to protect the body is by targeting abnormal antigen on the surface of the cancerous cells that have mutated.

So, all this shows the introduction and applications of immunotherapy through this blog. It is a leading therapy and a novel area of cancer research in recent years. It holds promises and is effective in treating various cancers in comparison to other traditional therapies such as radiation therapy, chemotherapy and surgery.

Global Allied Pharmaceuticals (GAP) has advanced treatment based on immunotherapy and immune combination therapy for various types of cancer. Additionally our company accompanies an expert and skilled team of researchers and oncologists which works effectively to meet the unmet meet of medication.

For more information, kindly visit us at www.gapsos.com

Is it possible to treat Renal cell carcinoma with Immune based therapy?

With the help of this blog we are going to let you know about the possibility of treating renal cell carcinoma with immune based therapy. Immunotherapy is one of the growing fields in cancer research in recent years. Renal cell carcinoma (RCC) is the most common type of renal cancer in adults that originates from the lining of proximal convoluted tubule (PCT) in the kidney. 

 

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According to the data presented by the SEER in 2014, it was estimated that approximately 63,920 new cases of renal cancer (39,140 in men and 24,780 in women) were identified and about 13,860 people (8,900 men and 4,960 women) get died from this disease in the U.S. The incidence and prevalence in males and females is in the ratio 1.5:1. 

The prevalence was estimated that there were 358,603 people alive with RCC in the United States in 2011. The RCC represents 3.8% of all cancer cases in the United States. 

The most common risk factors are body weight, smoking, hazards chemicals such as cadmium, and herbicide, inherited risk factors such as von Hippel Lindau disease, hereditary leiomyoma renal cell carcinoma, hereditary papillary renal cell carcinoma, and hereditary renal oncocytoma, and other risk factors are race, gender, high blood pressure and family history.

The treatment protocol includes monoclonal antibodies, kinase inhibitors, mTOR therapy, vaccines and proteasome inhibitor therapy.

The FDA approved monoclonal antibodies is Bevacizumab. 

In kinase inhibitors the FDA approved drugs are Sunitinib Malate, Sorafenib, Pazopanib, and Axitinib.

The FDA approved mTOR drug is Temsirolimus and Everolimus.

There are some vaccines that are not currently approved by FDA for RCC. However, many drugs are under clinical trials in phase I, II, and III such as AGS-003 and IL-2 (Aldesleukin).

There are some proteasome inhibitor drugs that are not currently approved by FDA for RCC. However, many drugs are under clinical trials in phase I, II, and III as Bortezomib and Carfilzomib.

Immunotherapy has proven to be effective in the treatment of renal cell carcinoma (RCC). Our success in treating RCC is increasing and advancing with the knowledge of the function of the immune system.

Global Allied Pharmaceuticals (GAP) has advanced treatment based on immunotherapy and immune combination therapy for various types of cancer. Additionally our company accompanies an expert and skilled team of researchers and oncologists which works effectively to meet the unmet meet of medication.

What is Dendritic cell based Immunotherapy and T cell Adoptive Transfer therapy.

In this blog we are going to serve the details of dendritic cell based Antibody Drug Conjugate and Adoptive T cell transfer therapy.

Regarding dendritic cell based therapy; one must know that dendritic cells have the ability to be stimulated to produce a cytotoxic response towards a certain antigen.

Mainly for this to happen, dendritic cells which are a type of cells that present antigens, are collected from a patient. Then these cells are either transfected with a unit of a virus or are pulsed with an antigen. When the sample is reintroduced into the patient, as a result of the activation of these cells, they present the tumor antigen into the lymphocyte effector, which is made of CD4, CD8, T Cells, and B cells.

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This leads to an initiation of a cytotoxic response to the cells that are expressing the tumor antigen. An example of this approach is Sipuleucel T which is used mainly to treat patients with metastatic prostate cancer (HRPC).

On the other hand, the Adoptive T cell transfer, is mainly the transfer of T cells to produce a cytotoxic effect to attack cancerous cells, naturally these types of cells are reactive to cancerous cells. To introduce them to patients, they are generated in vitro and then re-introduced to the patient.

An example of this was shown in a study where there is introduction of lymphocytes that were autologous and tumor penetrating as an effective treatment for metastatic melanoma. In accordance to this procedure, the following must occur:

First the T cells that are inside the tumor within the patient must be extracted. Then these T cells are trained to battle the tumor cells, usually these are referred to Tumor infiltrating lymphocytes (TIL).

Then they are grown in vitro using high concentration. Of allo-reactive feeder cells, IL2, & anti CD3. Then these T cells are transferred back and introduced into the patient with the administration of IL2 exogenously to further increase noticeably their anti-effect on cancer. This leads to about a 51 % objective response rate, and in some cases the tumors were undetectable in size.

Thus, in this way it has been introduced the details of dendritic cell based therapy and adoptive T cell transfer and it’s used for treatment.

Global Allied Pharmaceuticals is providing immunotherapy and immune-oncology services since more than 14 years. Contact us at www.gapsos.com.